Bought a new '25 AT4 1500 CarbonPro 3.0L in April - 5600 miles and this issue (no audio or turn signal sounds) crops up for me at least every couple of weeks. The truck is absolutely amazing in every other aspect besides that, but it sure is infuriating when it happens. The documented "fix" of shutting the truck off and coming back to it after ~10 minutes or restarting in safe mode and then starting the truck after ~2 minutes usually brings the audio back.
Been doing some digging and just wanted to post an update here: the previous PIT6101 service bulletin on this issue that was mentioned in post #8 in this thread has been superseded by PIT6406A, and now includes 2022-2025 Sierra 1500s (the previous bulletin only included 2023-2024 MYs). See here:
https://static.nhtsa.gov/odi/tsbs/2025/MC-11020688-0001.pdf
Curiously, replacement of the amplifier is still only a valid fix for the '23-'24 model years, and the '22 and '25 are not included in that. Overall, the whole thing smells like a software issue, full stop. I'd be curious to know if any of the previous posters (or the OP of this thread) have had their issue completely solved for extended time periods due to the amplifier swap.
(Oh, and this is my first post here - glad to be part of the community!)